Coronary endothelial dysfunction in humans is associated with myocardial perfusion defects.

  title={Coronary endothelial dysfunction in humans is associated with myocardial perfusion defects.},
  author={David Hasdai and Raymond J. Gibbons and D. R. Holmes and Stuart T. Higano and Amir Lerman},
  volume={96 10},
BACKGROUND Coronary endothelial dysfunction may occur in patients with minimally obstructive coronary artery disease and angina, and potentially may cause myocardial ischemia. METHODS AND RESULTS Coronary endothelium-dependent vasodilation was examined in patients with angina and <50% coronary artery diameter (CAD) stenosis by selectively infusing acetylcholine (10(-6) mol/L to 10(-4) mol/L) into the left anterior descending coronary artery (LAD). Percent change in CAD (%deltaCAD) was… CONTINUE READING


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