Coronary autoregulation and purine release in normoxic heart at various cytoplasmic phosphorylation potentials: disparate effects of adenosine

The impacts of energy-yielding substrates on coronary flow autoregulation, cytoplasmic phosphorylation potential {[ATP]/([ADP][Pi])} and purine nucleoside production were studied in Langendorff-perfused guinea pig hearts. The perfusion medium was substrate-free or contained glucose alone or in combination with pyruvate, lactate, acetate, or octanoate as… CONTINUE READING