Coronary artery injury and the biology of atherosclerosis: inflammation, thrombosis, and stabilization.

@article{Libby2000CoronaryAI,
  title={Coronary artery injury and the biology of atherosclerosis: inflammation, thrombosis, and stabilization.},
  author={Peter Libby},
  journal={The American journal of cardiology},
  year={2000},
  volume={86 8B},
  pages={3J-8J; discussion 8J-9J}
}
  • Peter Libby
  • Published 2000 in The American journal of cardiology
Conventional concepts of the pathogenesis of acute coronary syndromes are changing. High-risk lesions are not necessarily the angiographically "tight" stenoses. Rather, unstable vulnerable lesions have large lipid cores and thin fibrous caps. Plaque instability relates closely to the development of inflammation within the intima. Acute coronary syndromes usually result from rupture of a vulnerable atherosclerotic plaque mechanistically linked to the inflammatory process. Stabilization of… CONTINUE READING