Coronary artery disease-related genetic variant on chromosome 10q11 is associated with carotid intima-media thickness and atherosclerosis.

@article{Kiechl2010CoronaryAD,
  title={Coronary artery disease-related genetic variant on chromosome 10q11 is associated with carotid intima-media thickness and atherosclerosis.},
  author={Stefan Kiechl and Ross C. Laxton and Qingzhong Xiao and Jussi A Hernesniemi and Olli T. Raitakari and Mika K{\"a}h{\"o}nen and Bongani M. Mayosi and Antti M. Jula and Leena Moilanen and Johann Willeit and H. V. Watkins and Nilesh J. Samani and Terho Lehtim{\"a}ki and Bernard D Keavney and Qingbo Xu and Shu Ye},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2010},
  volume={30 12},
  pages={2678-83}
}
OBJECTIVE To investigate whether chromosome 10q11.21 influences common carotid intima-media thickness (IMT) and atherosclerosis and whether it is associated with stromal cell-derived factor-1α (SDF-1α) plasma levels. METHODS AND RESULTS Variation on chromosome 10q11.21 has been consistently associated with coronary artery disease. The genetic variant lies upstream of the gene encoding SDF-1α. We genotyped 3 population cohorts (Bruneck [age range, 45 to 94 years; 50.0% men; n=738], Health2000… CONTINUE READING

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The coronary heart disease - related variant at the 10q11.21 locus is associated with carotid IMT and atherosclerosis .
The coronary heart disease - related variant at the 10q11.21 locus is associated with carotid IMT and atherosclerosis .
The coronary heart disease - related variant at the 10q11.21 locus is associated with carotid IMT and atherosclerosis .
The coronary heart disease - related variant at the 10q11.21 locus is associated with carotid IMT and atherosclerosis .
The coronary heart disease - related variant at the 10q11.21 locus is associated with carotid IMT and atherosclerosis .
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