Coronary and uterine vascular responses to raloxifene in the sheep.

@article{Zoma2000CoronaryAU,
  title={Coronary and uterine vascular responses to raloxifene in the sheep.},
  author={Willie D Zoma and Robert S.U. Baker and Kenneth E. Clark},
  journal={American journal of obstetrics and gynecology},
  year={2000},
  volume={182 3},
  pages={
          521-8
        }
}
OBJECTIVE We sought to determine whether raloxifene increases coronary and uterine blood flow in ovariectomized ewes. STUDY DESIGN Twelve ewes were chronically instrumented for measurement of mean arterial pressure, heart rate, cardiac output, coronary blood flow, and uterine blood flow. Sheep received 17beta-estradiol, Estrace, raloxifene, or KY Jelly vehicle on separate days. RESULTS 17beta-Estradiol increased uterine blood flow from 21 +/- 3 to 254 +/- 36 mL/min and coronary blood flow… CONTINUE READING
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