Coronary and myocardial adenosine receptors.

Abstract

In the isolated guinea pig heart the rank oder of potency for coronary vasodilation is NECA greater than R-PIA greater than adenosine greater than S-PIA and this is characteristic for A2-adenosine receptors. Release of 3H-cyclic AMP from coronary endothelium in 3H-adenosine prelabeled hearts was augmented by these adenosine derivatives and followed the same… (More)

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