Coronaridine congeners decrease neuropathic pain in mice and inhibit α9α10 nicotinic acetylcholine receptors and CaV2.2 channels
@article{Arias2020CoronaridineCD, title={Coronaridine congeners decrease neuropathic pain in mice and inhibit $\alpha$9$\alpha$10 nicotinic acetylcholine receptors and CaV2.2 channels}, author={Hugo Rub{\'e}n Arias and Han-Shen Tae and Laura Micheli and Arsalan Yousuf and Carla Ghelardini and David John Adams and Lorenzo Di Cesare Mannelli}, journal={Neuropharmacology}, year={2020}, volume={175} }
7 Citations
(E)-3-Furan-2-yl-N-p-tolyl-acrylamide and its Derivative DM489 Decrease Neuropathic Pain in Mice Predominantly by α7 Nicotinic Acetylcholine Receptor Potentiation.
- Biology, ChemistryACS chemical neuroscience
- 2020
The electrophysiological results support the notion that α7 nAChR potentiation is likely the predominant molecular mechanism underlying the observed anti-nociceptive pain activity of these compounds.
(+)-Catharanthine potentiates the GABAA receptor by binding to a transmembrane site at the β(+)/α(-) interface near the TM2-TM3 loop.
- Biology, ChemistryBiochemical pharmacology
- 2022
Sultam based Carbonic Anhydrase VII inhibitors for the management of neuropathic pain.
- ChemistryEuropean journal of medicinal chemistry
- 2021
Virtual Screening and Hit Selection of Natural Compounds as Acetylcholinesterase Inhibitors
- Biology, ChemistryMolecules
- 2022
All available NCs in the ZINC12 database for AChE inhibitory activity and antioxidant activity were screened, and five compounds showed weak A cholinesterase inhibition and three of them exhibited high antioxidant activity.
Mechanism of interactions between α-conotoxin RegIIA and carbohydrates at the human α3β4 nicotinic acetylcholine receptor
- Biology, ChemistryMarine Life Science & Technology
- 2021
This study further clarifies the structure–activity relationship of α-conotoxin RegIIA at the hα3β4 nAChR and, also provides important experimental and theoretical basis for the development of new peptide drugs.
Steroidal Alkaloids with a Potent Analgesic Effect Based on N-type Calcium Channel Inhibition.
- Chemistry, BiologyOrganic letters
- 2021
Compounds 1 and 2 showed potent analgesic effects in vivo, superior to the well-known analgesic, pethidine (Dolantin), likely by inhibiting CaV2.2 voltage-gated calcium channels.
Bibliometric analysis of nicotinic acetylcholine receptors channel research (2000-2020)
- BiologyChannels
- 2021
The study provides a perspective to visualize and analyze hotspots and emerging trends in the nAChR channel and finds the USA and the Utah System of Higher Education were the most productive country and institution for nA ChR channel research.
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