Coronaridine congeners decrease neuropathic pain in mice and inhibit α9α10 nicotinic acetylcholine receptors and CaV2.2 channels

@article{Arias2020CoronaridineCD,
  title={Coronaridine congeners decrease neuropathic pain in mice and inhibit $\alpha$9$\alpha$10 nicotinic acetylcholine receptors and CaV2.2 channels},
  author={Hugo Rub{\'e}n Arias and Han-Shen Tae and Laura Micheli and Arsalan Yousuf and Carla Ghelardini and David John Adams and Lorenzo Di Cesare Mannelli},
  journal={Neuropharmacology},
  year={2020},
  volume={175}
}
View on Elsevier
ro.uow.edu.au
7 Citations
Background Citations
1

Figures and Tables from this paper

7 Citations

(E)-3-Furan-2-yl-N-p-tolyl-acrylamide and its Derivative DM489 Decrease Neuropathic Pain in Mice Predominantly by α7 Nicotinic Acetylcholine Receptor Potentiation.
TLDR
The electrophysiological results support the notion that α7 nAChR potentiation is likely the predominant molecular mechanism underlying the observed anti-nociceptive pain activity of these compounds.
(+)-Catharanthine potentiates the GABAA receptor by binding to a transmembrane site at the β(+)/α(-) interface near the TM2-TM3 loop.
Sultam based Carbonic Anhydrase VII inhibitors for the management of neuropathic pain.
Virtual Screening and Hit Selection of Natural Compounds as Acetylcholinesterase Inhibitors
TLDR
All available NCs in the ZINC12 database for AChE inhibitory activity and antioxidant activity were screened, and five compounds showed weak A cholinesterase inhibition and three of them exhibited high antioxidant activity.
Mechanism of interactions between α-conotoxin RegIIA and carbohydrates at the human α3β4 nicotinic acetylcholine receptor
TLDR
This study further clarifies the structure–activity relationship of α-conotoxin RegIIA at the hα3β4 nAChR and, also provides important experimental and theoretical basis for the development of new peptide drugs.
Steroidal Alkaloids with a Potent Analgesic Effect Based on N-type Calcium Channel Inhibition.
TLDR
Compounds 1 and 2 showed potent analgesic effects in vivo, superior to the well-known analgesic, pethidine (Dolantin), likely by inhibiting CaV2.2 voltage-gated calcium channels.
Bibliometric analysis of nicotinic acetylcholine receptors channel research (2000-2020)
TLDR
The study provides a perspective to visualize and analyze hotspots and emerging trends in the nAChR channel and finds the USA and the Utah System of Higher Education were the most productive country and institution for nA ChR channel research.

References

SHOWING 1-10 OF 51 REFERENCES
Coronaridine congeners potentiate GABAA receptors and induce sedative activity in mice in a benzodiazepine-insensitive manner
Selectivity of coronaridine congeners at nicotinic acetylcholine receptors and inhibitory activity on mouse medial habenula.
Coronaridine congeners inhibit human α3β4 nicotinic acetylcholine receptors by interacting with luminal and non-luminal sites.
Inhibition of α9α10 nicotinic acetylcholine receptors prevents chemotherapy-induced neuropathic pain
TLDR
It is established that a highly selective and potent inhibitor of the α9α10 nicotinic acetylcholine receptor (nAChR) subtype prevents the expression of chemotherapy-induced neuropathic pain, and that α9-containing nAChRs are a critical target for prevention of chronic cancer chemotherapy- induced neuropathicPain.
RgIA4 Potently Blocks Mouse α9α10 nAChRs and Provides Long Lasting Protection against Oxaliplatin-Induced Cold Allodynia
TLDR
It is demonstrated that Rgia4 analgesic effects following oxaliplatin treatment are sustained for 21 days after last RgIA4 administration indicating that R gIA4 may provide enduring protection against nerve damage.
Effects of natural and synthetic isothiocyanate-based H2S-releasers against chemotherapy-induced neuropathic pain: Role of Kv7 potassium channels
Structure-Activity Studies Reveal the Molecular Basis for GABAB-Receptor Mediated Inhibition of High Voltage-Activated Calcium Channels by α-Conotoxin Vc1.1.
TLDR
Findings suggest that selectively targeting GABABR-mediated HVA calcium channel inhibition by α-conotoxins could be effective for the treatment of chronic visceral pain.
Pharmacological Inhibition of Voltage-gated Ca2+ Channels for Chronic Pain Relief
TLDR
Development of VGCC subtype inhibitors and targeting them into nociceptors will contribute to a better understanding of the roles ofVGCC subtypes in pain at a spinal level as well as development of a novel class of analgesics for chronic pain.
Alpha9 nicotinic acetylcholine receptors and the treatment of pain.
Analgesic conotoxins: block and G protein‐coupled receptor modulation of N‐type (CaV2.2) calcium channels
TLDR
A series of newly discovered ω‐conotoxins from Conus catus, including CVID–F, are potent and selective antagonists of N‐type VGCCs and will lead to new ways to regulate VGCC block and modulation in normal and diseased states of the nervous system.
...
...