Cornichon2 Dictates the Time Course of Excitatory Transmission at Individual Hippocampal Synapses

@article{Boudkkazi2014Cornichon2DT,
  title={Cornichon2 Dictates the Time Course of Excitatory Transmission at Individual Hippocampal Synapses},
  author={Sami Boudkkazi and Aline Br{\'e}chet and Jochen Schwenk and Bernd Fakler},
  journal={Neuron},
  year={2014},
  volume={82},
  pages={848-858}
}
Cornichon2 (CNIH2), an integral component of AMPA receptor (AMPAR) complexes in the mammalian brain, slows deactivation and desensitization of heterologously reconstituted receptor channels. Its significance in neuronal signal transduction, however, has remained elusive. Here we show by paired recordings that CNIH2-containing AMPARs dictate the slow decay of excitatory postsynaptic currents (EPSCs) elicited in hilar mossy cells of the hippocampus by single action potentials in mossy fiber… CONTINUE READING
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