Corneodesmosin gene: no evidence for PSORS 1 gene in North-eastern Thai psoriasis patients.

@article{Romphruk2003CorneodesmosinGN,
  title={Corneodesmosin gene: no evidence for PSORS 1 gene in North-eastern Thai psoriasis patients.},
  author={A V Romphruk and A. A. Kompiang Oka and Arunrat Romphruk and Maiko Tomizawa and Charoen Choonhakarn and Takuji Naruse and Chintana Puapairoj and Gen Tamiya and Chanvit Leelayuwat and Hidetoshi Inoko},
  journal={Tissue antigens},
  year={2003},
  volume={62 3},
  pages={217-24}
}
Psoriasis vulgaris, a common inflammatory skin disorder, is known to be associated with the HLA-Cw*06 allele. It has been recently suggested by microsatellite mapping that a real susceptible gene for psoriasis resides in the approximately 100-kb genomic region telomeric of the HLA-C gene. In this respect, the corneodesmosin (CDSN) gene 160-kb telomeric of HLA-C is a strong candidate because of its location and its functional role in corneocyte cohesion and desquamation. In fact, a significant… CONTINUE READING