Corneal pharmacokinetics of topically applied azithromycin and clarithromycin.

Abstract

PURPOSE To determine corneal levels of topically administered azithromycin and clarithromycin in a rabbit model. DESIGN Experimental animal study. METHODS Corneas of New Zealand albino rabbits were treated with topical azithromycin (2 mg/ml or 4 mg/ml) or clarithromycin (10 mg/ml). Topical azithromycin was prepared from an intravenous solution and… (More)

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