Corneal and conjunctival/scleral penetration of p-aminoclonidine, AGN 190342, and clonidine in rabbit eyes.

@article{Chien1990CornealAC,
  title={Corneal and conjunctival/scleral penetration of p-aminoclonidine, AGN 190342, and clonidine in rabbit eyes.},
  author={Dao-Ngoc Chien and J J Homsy and Charles Gluchowski and Diane D-S Tang-Liu},
  journal={Current eye research},
  year={1990},
  volume={9 11},
  pages={1051-9}
}
The ocular penetration pathways of three alpha 2-adrenergic agents (p-aminoclonidine, AGN 190342, and clonidine) were investigated in rabbits both in vitro and in vivo. The corneal permeabilities of the compounds correlated positively with their octanol/water distribution coefficients. The ocular drug absorption via corneal and conjunctival/scleral penetration routes was evaluated separately after drug perfusion in vivo. In most cases, the corneal route was the major pathway for the intraocular… CONTINUE READING

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