Corneal allografts fail to express Ia antigens

@article{Streilein1979CornealAF,
  title={Corneal allografts fail to express Ia antigens},
  author={J. Wayne Streilein and Galen B. Toews and Paul R. Bergstresser},
  journal={Nature},
  year={1979},
  volume={282},
  pages={326-327}
}
Although the surface determinants encoded by class I genes of the major histocompatibility complex (murine K/D; human HLA-A/B/C) are expressed on virtually all nucleated cells, the molecular products of class II genes (murine I, human HLA-D/DR) are expressed only on B lymphocytes, macrophages, sperm and certain subsets of T lymphocytes, especially suppressor cells1,2. Controversy exists concerning the expression of class II antigens on cells of the epidermis. On the one hand, Hammerling et al.3… CONTINUE READING