Corneal Cross-Linking-Induced Stromal Demarcation Line

@article{Seiler2006CornealCS,
  title={Corneal Cross-Linking-Induced Stromal Demarcation Line},
  author={Theo G. Seiler and Farhad Hafezi},
  journal={Cornea},
  year={2006},
  volume={25},
  pages={1057-1059}
}
Purpose: Corneal collagen cross-linking by UVA/riboflavin (X-linking) represents a new method for the treatment of progressive keratoconus and currently is under clinical study. To avoid UVA irradiation damage to the corneal endothelium, the parameters for X-linking are set in a way that effective treatment occurs only in the first 300 μm of the corneal stroma. Here, X-linking not only strengthens the biomechanical properties of the cornea but also induces keratocyte apoptosis. To date, the… 
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Corneal Collagen Cross-Linking
TLDR
The major indication for the use of CXL is to inhibit the progression of corneal ectasias, such as keratoconus and pellucid marginal degeneration, and may also be effective in the treatment and prophylaxis of iatrogenic keratectasia, resulting from excessively aggressive photoablation.
Increased Reaction after Cross-linking in Keratoconus Melanoderm Patients
TLDR
Increased stromal reaction observed in 4 eyes of 3 melanoderm patients who underwent CXL for evolutive keratoconus is described, indicating probably the efficiency of the procedure.
Corneal Collagen Cross-Linking for Keratoconus and Corneal Ectasia
TLDR
It is reasonable to consider all eyes with progressive keratoconus or corneal ectasia for cross-linking treatment; however, eyes with good visual acuity may be somewhat more susceptible to a loss of 1 Snellen line of acuity after CXL.
Corneal stromal demarcation line after collagen cross-linking in corneal ectatic diseases: a review of the literature
TLDR
Evaluation of demarcation line (DL), a transition zone between the cross-linked anterior corneal stroma and the untreated posterior cornea, is considered a measurement of the depth of CXL treatment into the stroma, which indicates effectiveness of the CXL.
Corneal collagen cross-linking (CXL) in thin corneas
TLDR
The overall safety and efficacy of the modified CXL protocols are good, as most of them managed to halt the progression of keratectasia without postoperative complications, but controlled studies with long-term follow-up are required.
Reduced cross-linking demarcation line depth at the peripheral cornea after corneal collagen cross-linking.
TLDR
Both the CXL demarcation line depth and its proportion over the corneal thickness were greater at the central cornea than the peripheral cornea.
Epithelium-Off Corneal Cross-Linking
  • F. Raiskup
  • Medicine, Biology
    Controversies in the Management of Keratoconus
  • 2018
TLDR
The chapter describes briefly standard “Dresden protocol” and also accelerated mode of CXL treatment, and the importance of medical history of the patient, evidence of the progression of keratoconus and possible complications after the procedure are turned to.
Collagen Cross Linking in Keratoconus: A Review
TLDR
The modifications in CXL halt the progression of keratectasia without postoperative complications and the evidence of safety and efficacy in the use of modified CXL protocols is still limited to few studies with few patients involved.
Marked remodelling of the anterior corneal surface following collagen cross-linking with riboflavin and UVA
TLDR
Three cases that did not display regression but rather displayed a massive remodelling with Kmax reduction of up to 9.5 dioptres (D), accompanied by formation of a deep stromal opacity and a distinct increase in best spectacle-corrected visual acuity (BSCVA) are reported.
Corneal collagen cross-linking following superficial keratectomy as treatment for corneal endothelial cell dystrophy in dogs: Preliminary clinical study.
TLDR
Collagen cross-linking with SK has the potential to reduce the corneal thickness in CED cases; however, a lasting clinically significant improvement of corneAL transparency seems unlikely.
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TLDR
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TLDR
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TLDR
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TLDR
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