Corin in natriuretic peptide processing and hypertension.

  title={Corin in natriuretic peptide processing and hypertension.},
  author={Yiqing Zhou and Qingyu Wu},
  journal={Current hypertension reports},
  volume={16 2},
Corin is a serine protease originally isolated from the heart. Functional studies show that corin is the long-sought enzyme responsible for activating cardiac natriuretic peptides. In mice, lack of corin prevents natriuretic peptide processing, causing salt-sensitive hypertension. In humans, corin variants and mutations that reduce corin activity have been identified in patients with hypertension and heart failure. Decreased plasma levels of corin antigen and activity have been reported in… CONTINUE READING