Corin: new insights into the natriuretic peptide system.

  title={Corin: new insights into the natriuretic peptide system.},
  author={Qingyu Wu and Ye Olivia Xu-Cai and Shenghan Chen and Wei Wang},
  journal={Kidney international},
  volume={75 2},
Natriuretic peptides are important in regulating salt and body-fluid balance. In cells, these peptides are made as precursor forms that are converted to active forms by proteolyic processing. Corin is a transmembrane serine protease identified in the heart. Corin converts pro-atrial natriuretic peptide (pro-ANP) to active ANP in a sequence-specific manner. In mice, lack of corin prevents the conversion of pro-ANP to ANP and causes salt-sensitive hypertension. The hypertensive phenotype is… CONTINUE READING