Corepressors selectively control the transcriptional activity of PPARgamma in adipocytes.

  title={Corepressors selectively control the transcriptional activity of PPARgamma in adipocytes.},
  author={Hong-Ping Guan and Takahiro Ishizuka and Patricia C. Chui and Michael Lehrke and Mitchell A Lazar},
  journal={Genes & development},
  volume={19 4},
Peroxisome proliferator-activated receptor gamma (PPARgamma) is the master regulator of adipogenesis as well as the target of thiazolidinedione (TZD) antidiabetic drugs. Many PPARgamma target genes are induced during adipogenesis, but others, such as glycerol kinase (GyK), are expressed at low levels in adipocytes and dramatically up-regulated by TZDs. Here, we have explored the mechanism whereby an exogenous PPARgamma ligand is selectively required for adipocyte gene expression. The GyK gene… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 129 extracted citations

The toxicology of ligands for peroxisome proliferator-activated receptors (PPAR).

Toxicological sciences : an official journal of the Society of Toxicology • 2006
View 5 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…