Corepressor-Dependent Silencing of Chromosomal Regions Encoding Neuronal Genes

@article{Lunyak2002CorepressorDependentSO,
  title={Corepressor-Dependent Silencing of Chromosomal Regions Encoding Neuronal Genes},
  author={V. Lunyak and R. Burgess and G. Prefontaine and C. Nelson and S. Sze and J. Chenoweth and P. Schwartz and P. Pevzner and C. Glass and G. Mandel and M. Rosenfeld},
  journal={Science},
  year={2002},
  volume={298},
  pages={1747 - 1752}
}
  • V. Lunyak, R. Burgess, +8 authors M. Rosenfeld
  • Published 2002
  • Medicine, Biology
  • Science
  • The molecular mechanisms by which central nervous system–specific genes are expressed only in the nervous system and repressed in other tissues remain a central issue in developmental and regulatory biology. Here, we report that the zinc-finger gene-specific repressor element RE-1 silencing transcription factor/neuronal restricted silencing factor (REST/NRSF) can mediate extraneuronal restriction by imposing either active repression via histone deacetylase recruitment or long-term gene… CONTINUE READING
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