Corepressor CtBP1 interacts with and specifically inhibits CBP activity.

  title={Corepressor CtBP1 interacts with and specifically inhibits CBP activity.},
  author={Vitalyi Senyuk and Kislay K Sinha and Giuseppina Nucifora},
  journal={Archives of biochemistry and biophysics},
  volume={441 2},
Transcription repression in eukaryotes is mediated by a wide variety of transcription factors that usually recruit corepressors and form corepressor complexes at the specific promoter sites. One of these corepressors is the C-terminal-binding protein (CtBP) which was first identified as a protein that binds to the C-terminal region of the adenovirus E1A protein. CtBP has a strong role in both development and oncogenesis. Till date, the mechanism of transcription repression by CtBP is unknown… CONTINUE READING


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