Corelease of two fast neurotransmitters at a central synapse.

  title={Corelease of two fast neurotransmitters at a central synapse.},
  author={Peter Jonas and Josef Bischofberger and J{\"u}rgen Sandk{\"u}hler},
  volume={281 5375},
It is widely accepted that individual neurons in the central nervous system release only a single fast transmitter. The possibility of corelease of fast neurotransmitters was examined by making paired recordings from synaptically connected neurons in spinal cord slices. Unitary inhibitory postsynaptic currents generated at interneuron-motoneuron synapses consisted of a strychnine-sensitive, glycine receptor-mediated component and a bicuculline-sensitive, gamma-aminobutyric acid (GABA)A receptor… 

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Cotransmission of acetylcholine and GABA

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Involvement of GABA and glycine in recurrent inhibition of spinal motoneurons.

The results suggest that both glycinergic and GABAergic mechanisms play a role in recurrent inhibition of motoneurons in the mammalian spinal cord and suggest that a major portion of the strychnine-resistant component of the IPSP is mediated by a GABAergic mechanism.

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