Coregulation of vascular tube stabilization by endothelial cell TIMP-2 and pericyte TIMP-3

@article{Saunders2006CoregulationOV,
  title={Coregulation of vascular tube stabilization by endothelial cell TIMP-2 and pericyte TIMP-3},
  author={William B. Saunders and Brenda L. Bohnsack and Jennifer B. Faske and Nicholas J. Anthis and Kayla J. Bayless and Karen K Hirschi and George E Davis},
  journal={The Journal of Cell Biology},
  year={2006},
  volume={175},
  pages={179 - 191}
}
The endothelial cell (EC)-derived tissue inhibitor of metalloproteinase-2 (TIMP-2) and pericyte-derived TIMP-3 are shown to coregulate human capillary tube stabilization following EC-pericyte interactions through a combined ability to block EC tube morphogenesis and regression in three-dimensional collagen matrices. EC-pericyte interactions strongly induce TIMP-3 expression by pericytes, whereas ECs produce TIMP-2 in EC-pericyte cocultures. Using small interfering RNA technology, the… CONTINUE READING

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