Coregulation of transcription factors and microRNAs in human transcriptional regulatory network

@inproceedings{Chen2011CoregulationOT,
  title={Coregulation of transcription factors and microRNAs in human transcriptional regulatory network},
  author={Cho-Yi Chen and Shui-Tein Chen and Chiou-Shann Fuh and Hsueh-Fen Juan and Hsuan-Cheng Huang},
  booktitle={BMC Bioinformatics},
  year={2011}
}
MicroRNAs (miRNAs) are small RNA molecules that regulate gene expression at the post-transcriptional level. Recent studies have suggested that miRNAs and transcription factors are primary metazoan gene regulators; however, the crosstalk between them still remains unclear. We proposed a novel model utilizing functional annotation information to identify significant coregulation between transcriptional and post-transcriptional layers. Based on this model, function-enriched coregulation… CONTINUE READING
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