Coreceptor utilization by human immunodeficiency virus type 1 is not a primary determinant of neutralization sensitivity.

@article{Lacasse1998CoreceptorUB,
  title={Coreceptor utilization by human immunodeficiency virus type 1 is not a primary determinant of neutralization sensitivity.},
  author={Rachel A. Lacasse and Kathryn E. Follis and Tarsem L. Moudgil and Meg Trahey and James M Binley and Vicente Planelles and Susan Zolla-Pazner and Jack H. Nunberg},
  journal={Journal of virology},
  year={1998},
  volume={72 3},
  pages={
          2491-5
        }
}
We have examined the relationship between coreceptor utilization and sensitivity to neutralization in a primary isolate of human immunodeficiency virus type 1 and its T-cell line-adapted (TCLA) derivative. We determined that adaptation of the primary-isolate (PI) virus 168P results in the loss of the unique capacity of PI viruses to utilize the CCR5 coreceptor and in the acquisition by the TCLA 168C virus of sensitivity to neutralization by V3-directed monoclonal antibodies (MAbs). In… CONTINUE READING

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