Coreceptor competition for association with CD4 may change the susceptibility of human cells to infection with T-tropic and macrophagetropic isolates of human immunodeficiency virus type 1.

@article{Lee2000CoreceptorCF,
  title={Coreceptor competition for association with CD4 may change the susceptibility of human cells to infection with T-tropic and macrophagetropic isolates of human immunodeficiency virus type 1.},
  author={Sherwin Lee and Cheryl K. Lapham and Huiyuan Chen and Lynn King and Jody Manischewitz and Tatiana Romantseva and Howard S. Mostowski and Tzanko Stantchev and Christopher C. Broder and H. Golding},
  journal={Journal of virology},
  year={2000},
  volume={74 11},
  pages={5016-23}
}
The chemokine receptors CCR5 and CXCR4 were found to function in vivo as the principal coreceptors for M-tropic and T-tropic human immunodeficiency virus (HIV) strains, respectively. Since many primary cells express multiple chemokine receptors, it was important to determine if the efficiency of virus-cell fusion is influenced not only by the presence of the appropriate coreceptor (CXCR4 or CCR5) but also by the levels of other coreceptors expressed by the same target cells. We found that in… CONTINUE READING
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