Coreactivation of Human Herpesvirus 6 and Cytomegalovirus Is Associated With Worse Clinical Outcome in Critically Ill Adults.

@article{Roa2015CoreactivationOH,
  title={Coreactivation of Human Herpesvirus 6 and Cytomegalovirus Is Associated With Worse Clinical Outcome in Critically Ill Adults.},
  author={Paula L{\'o}pez Roa and Joshua A Hill and Katharine A. Kirby and Wendy M Leisenring and Meei-li Huang and Tracy K Santo and Keith R. Jerome and Michael Boeckh and Ajit P Limaye},
  journal={Critical care medicine},
  year={2015},
  volume={43 7},
  pages={1415-22}
}
OBJECTIVES Human herpesvirus 6 is associated with a variety of complications in immunocompromised patients, but no studies have systematically and comprehensively assessed the impact of human herpesvirus 6 reactivation, and its interaction with cytomegalovirus, in ICU patients. DESIGN We prospectively assessed human herpesvirus 6 and cytomegalovirus viremia by twice-weekly plasma polymerase chain reaction in a longitudinal cohort study of 115 adult, immunocompetent ICU patients. The… CONTINUE READING
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