Core-specific adaptive regulatory T-cells in different outcomes of hepatitis C.

  title={Core-specific adaptive regulatory T-cells in different outcomes of hepatitis C.},
  author={Bettina Langhans and Ingrid Braunschweiger and Simone Arndt and Wibke Schulte and Judith Satoguina and Laura E. Layland and Natascha Vidovic and Achim Hoerauf and Johannes Oldenburg and Tilman Sauerbruch and Ulrich Spengler},
  journal={Clinical science},
  volume={119 2},
CD4+ Treg-cells (regulatory T-cells) probably contribute to the impaired virus-specific T-cell responses in chronic HCV (hepatitis C virus) infection; however, their antigen-specificity has remained elusive. In the present study, we analysed peripheral blood CD4+ Treg-cells in patients with chronic hepatitis C and subjects with self-limited HCV infection and characterized individual Treg-cell clones obtained from both groups at the phenotypic and functional level. Foxp3 (forkhead box p3)+CD25… CONTINUE READING


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Function suppression

S. Smyk-Pearson, L. Golden-Mason, +7 authors H. R. Rosen

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