Core-shell silica nanoparticles as fluorescent labels for nanomedicine.

  title={Core-shell silica nanoparticles as fluorescent labels for nanomedicine.},
  author={Jinhyang Choi and Andrew A Burns and Rebecca M. E. Williams and Zongxiang Zhou and Andrea Flesken-Nikitin and Warren R. Zipfel and Ulrich B Wiesner and Alexander Yu Nikitin},
  journal={Journal of biomedical optics},
  volume={12 6},
Progress in biomedical imaging depends on the development of probes that combine low toxicity with high sensitivity, resolution, and stability. Toward that end, a new class of highly fluorescent core-shell silica nanoparticles with narrow size distributions and enhanced photostability, known as C dots, provide an appealing alternative to quantum dots. Here, C dots are evaluated with a particular emphasis on in-vivo applications in cancer biology. It is established that C dots are nontoxic at… CONTINUE READING