Core-shell nanocapsules stabilized by single-component polymer and nanoparticles for magneto-chemotherapy/hyperthermia with multiple drugs.

Abstract

Iron-oxide-containing double emulsion capsules carrying both hydrophilic and hydrophobic therapeutic molecules can deliver drugs and energy on demand in vivo. Magneto-chemotherapy/hyperthermia involves a burst-like release of hydrophilic doxorubicin and hydrophobic paclitaxel, remotely triggered by a high frequency magnetic field, which also releases energy via internalized iron oxide nanoparticles, all contributing to cell kill.

DOI: 10.1002/adma.201201251

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@article{Hu2012CoreshellNS, title={Core-shell nanocapsules stabilized by single-component polymer and nanoparticles for magneto-chemotherapy/hyperthermia with multiple drugs.}, author={Shang-Hsiu Hu and Bang-Jie Liao and Chin-Sheng Chiang and Po-Jung Chen and I-Wei Chen and San-Yuan Chen}, journal={Advanced materials}, year={2012}, volume={24 27}, pages={3627-32} }