Core-shell microencapsulation of curcumin in PLGA microparticles: programmed for application in ovarian cancer therapy.

@article{Dwivedi2018CoreshellMO,
  title={Core-shell microencapsulation of curcumin in PLGA microparticles: programmed for application in ovarian cancer therapy.},
  author={Pankaj Dwivedi and Shuai Yuan and Shuya Han and Farhana Akbar Mangrio and Zhiqiang Zhu and Fan Lei and Zhang Jun Ming and Lei Cheng and Zhongfa Liu and Ting Si and Ronald X Xu},
  journal={Artificial cells, nanomedicine, and biotechnology},
  year={2018},
  volume={46 sup3},
  pages={
          S481-S491
        }
}
In our study, we have established a novel liquid-driven co-flow focusing (LDCF) process to fabricate curcumin (CUR)-loaded poly (lactic-co-glycolic acid) (PLGA) microparticles (CPMs). LDCF-CPMs of size 20.26 ± 2.37 μm have high encapsulation efficiency (>70%) and were intended for application in ovarian cancer by intraperitoneal (IP) administration. LDCF-CPMs have smooth surface with narrow size distribution and a core-shell structured verified by confocal microscopy which can be precisely… CONTINUE READING