Core promoter specificities of the Sp1 and VP16 transcriptional activation domains.

  title={Core promoter specificities of the Sp1 and VP16 transcriptional activation domains.},
  author={Kamyar Emami and William Wiley Navarre and Stephen T. Smale},
  journal={Molecular and cellular biology},
  volume={15 11},
The core promoter compositions of mammalian protein-coding genes are highly variable; some contain TATA boxes, some contain initiator (Inr) elements, and others contain both or neither of these basal elements. The underlying reason for this heterogeneity remains a mystery, as recent studies have suggested that TATA-containing and Inr-containing core promoters direct transcription initiation by similar mechanisms and respond similarly to a wide variety of upstream activators. To analyze in… CONTINUE READING


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