Core promoter STRs: novel mechanism for inter-individual variation in gene expression in humans.

@article{Heidari2012CorePS,
  title={Core promoter STRs: novel mechanism for inter-individual variation in gene expression in humans.},
  author={Atta Heidari and Ziba Nariman Saleh Fam and Elika Esmaeilzadeh-Gharehdaghi and Mehdi Banan and Saman Hosseinkhani and Saeid Mohammadparast and Morteza Oladnabi and Mohammad Reza Ebrahimpour and Mohsen Soosanabadi and Tayebeh Farokhashtiani and Hossein Darvish and Saghar Ghasemi Firouzabadi and Samaneh Farashi and Hossein Najmabadi and M Ohadi},
  journal={Gene},
  year={2012},
  volume={492 1},
  pages={195-8}
}
In a genome-scale analysis of the composition of core promoter sequences, we have recently shown that approximately 25% of the human protein-coding genes have at least one short tandem repeat (STR) of 3-repeats in their core promoters (i.e. the interval between -120 to +1). Through their nucleosome processing effect, GA-repeats play a crucial role in the regulation of gene transcription. In this study, we chose the human SRY (sex determining region Y)-box 5 (SOX5) gene as a prototype of the GA… CONTINUE READING
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