Core human mitochondrial transcription apparatus is a regulated two-component system in vitro.

@article{Shutt2010CoreHM,
  title={Core human mitochondrial transcription apparatus is a regulated two-component system in vitro.},
  author={Timothy E. Shutt and Maria Fernanda Lodeiro and Justin Cotney and Craig E Cameron and Gerald S Shadel},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 27},
  pages={12133-8}
}
The core human mitochondrial transcription apparatus is currently regarded as an obligate three-component system comprising the bacteriophage T7-related mitochondrial RNA polymerase, the rRNA methyltransferase-related transcription factor, h-mtTFB2, and the high mobility group box transcription/DNA-packaging factor, h-mtTFA/TFAM. Using a faithful recombinant human mitochondrial transcription system from Escherichia coli, we demonstrate that specific initiation from the mtDNA promoters, LSP and… CONTINUE READING

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