Core glycosylation of collagen is initiated by two beta(1-O)galactosyltransferases.

@article{Schegg2009CoreGO,
  title={Core glycosylation of collagen is initiated by two beta(1-O)galactosyltransferases.},
  author={Belinda Schegg and Andreas J. H{\"u}lsmeier and Christoph Rutschmann and Charlotte Maag and Thierry Hennet},
  journal={Molecular and cellular biology},
  year={2009},
  volume={29 4},
  pages={943-52}
}
Collagen is a trimer of three left-handed alpha chains representing repeats of the motif Gly-X-Y, where (hydroxy)proline and (hydroxy)lysine residues are often found at positions X and Y. Selected hydroxylysines are further modified by the addition of galactose and glucose-galactose units. Collagen glycosylation takes place in the endoplasmic reticulum before triple-helix formation and is mediated by beta(1-O)galactosyl- and alpha(1-2)glucosyltransferase enzymes. We have identified two collagen… CONTINUE READING

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