Core-crosslinked pH-sensitive degradable micelles: A promising approach to resolve the extracellular stability versus intracellular drug release dilemma.

@article{Wu2012CorecrosslinkedPD,
  title={Core-crosslinked pH-sensitive degradable micelles: A promising approach to resolve the extracellular stability versus intracellular drug release dilemma.},
  author={Yali Wu and Wei Chen and Fenghua Meng and Zhongjuan Wang and Ru Yue Cheng and Chao Deng and Hongmei Liu and Zhiyuan Zhong},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2012},
  volume={164 3},
  pages={338-45}
}
The extracellular stability versus intracellular drug release dilemma has been a long challenge for micellar drug delivery systems. Here, core-crosslinked pH-sensitive degradable micelles were developed based on poly(ethylene glycol)-b-poly(mono-2,4,6-trimethoxy benzylidene-pentaerythritol carbonate-co-acryloyl carbonate) (PEG-b-P(TMBPEC-co-AC)) diblock copolymer that contains acid-labile acetal and photo-crossslinkable acryloyl groups in the hydrophobic polycarbonate block for intracellular… CONTINUE READING
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