Core-binding factors in hematopoiesis and immune function

Abstract

Core binding factors are heterodimeric transcription factors containing a DNA binding Runx1, Runx2, or Runx3 subunit, along with a non DNA binding CBFβ subunit. All four subunits are required at one or more stages of hematopoiesis. This review describes the role of Runx1 and CBFβ in the initiation of hematopoiesis in the embryo, and in the emergence of… (More)
DOI: 10.1038/sj.onc.1207763

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