Core antigen mutations of human hepatitis B virus in hepatomas accumulate in MHC class II-restricted T cell epitopes.

@article{Hosono1995CoreAM,
  title={Core antigen mutations of human hepatitis B virus in hepatomas accumulate in MHC class II-restricted T cell epitopes.},
  author={Seiyu Hosono and Prof. Cheng-Chi Tai and Wen-liang Wang and Mark Ambrose and Dick Guang-Iong Hwang and T T Yuan and Benjamin H Peng and Chung S Yang and Chun Seok Lee and Chiaho Shih},
  journal={Virology},
  year={1995},
  volume={212 1},
  pages={151-62}
}
Despite the extensive molecular information on serum-derived human hepatitis B viruses (HBV), liver-derived replicative HBV genomes have remained largely uninvestigated. We have examined the sequences of the entire core antigen (nucleocapsid) of liver-derived HBVs in 15 different hepatoma patients. Bona fide mutations, rather than subtype polymorphism, have been identified based on the high-frequency occurrence of structural differences from wild type at the highly evolutionarily conserved… CONTINUE READING

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