Core and penumbral nitric oxide synthase activity during cerebral ischemia and reperfusion.

@article{Ashwal1998CoreAP,
  title={Core and penumbral nitric oxide synthase activity during cerebral ischemia and reperfusion.},
  author={Stephen Ashwal and Beatriz Tone and Hou Rou Tian and Daniel J. Cole and W J Pearce},
  journal={Stroke},
  year={1998},
  volume={29 5},
  pages={1037-46; discussion 1047}
}
BACKGROUND AND PURPOSE The present studies examined the hypothesis that the distribution of cerebral injury after a focal ischemic insult is associated with the regional distribution of nitric oxide synthase (NOS) activity. METHODS Based on previous studies that certain anatomically well-defined areas are prone to become either core or penumbra after middle cerebral artery occlusion (MCAO), we measured NOS activity in these areas from the right and left hemispheres in a spontaneously… CONTINUE READING
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