Core Transcriptional Regulatory Circuitry in Human Embryonic Stem Cells

@article{Boyer2005CoreTR,
  title={Core Transcriptional Regulatory Circuitry in Human Embryonic Stem Cells},
  author={Laurie A. Boyer and Tong Ihn Lee and Megan F. Cole and Sarah E. Johnstone and Stuart S Levine and Jacob P. Zucker and Matthew G. Guenther and R. M. Satheesh Kumar and Heather Leanne Murray and Richard G Jenner and David Kenneth Gifford and Douglas A Melton and Rudolf Jaenisch and Richard A Young},
  journal={Cell},
  year={2005},
  volume={122},
  pages={947-956}
}
The transcription factors OCT4, SOX2, and NANOG have essential roles in early development and are required for the propagation of undifferentiated embryonic stem (ES) cells in culture. To gain insights into transcriptional regulation of human ES cells, we have identified OCT4, SOX2, and NANOG target genes using genome-scale location analysis. We found, surprisingly, that OCT4, SOX2, and NANOG co-occupy a substantial portion of their target genes. These target genes frequently encode… CONTINUE READING
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MicroRNAs: a developing story.

  • Current opinion in genetics & development
  • 2005
VIEW 1 EXCERPT