Core Structure of gp41 from the HIV Envelope Glycoprotein

@article{Chan1997CoreSO,
  title={Core Structure of gp41 from the HIV Envelope Glycoprotein},
  author={D. Chan and D. Fass and J. Berger and P. S. Kim},
  journal={Cell},
  year={1997},
  volume={89},
  pages={263-273}
}
The envelope glycoprotein of human immunodeficiency virus type 1 (HIV-1) consists of a complex of gp120 and gp41. gp120 determines viral tropism by binding to target-cell receptors, while gp41 mediates fusion between viral and cellular membranes. Previous studies identified an alpha-helical domain within gp41 composed of a trimer of two interacting peptides. The crystal structure of this complex, composed of the peptides N36 and C34, is a six-helical bundle. Three N36 helices form an interior… Expand
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