Core Fucosylation of the T Cell Receptor Is Required for T Cell Activation

@inproceedings{Liang2018CoreFO,
  title={Core Fucosylation of the T Cell Receptor Is Required for T Cell Activation},
  author={Wei Liang and Shanshan Mao and Shijie Sun and Ming Li and Zhi Li and Rui Yu and Tonghui Ma and Jianguo G Gu and Jianing Zhang and Naoyuki Taniguchi and Wenzhe Li},
  booktitle={Front. Immunol.},
  year={2018}
}
CD4+ T cell activation promotes the pathogenic process of systemic lupus erythematosus (SLE). T cell receptor (TCR) complex are highly core fucosylated glycoproteins, which play important roles in T cell activation. In this study, we found that the core fucosylation of CD4+ T cells was significantly increased in SLE patients. Loss of core fucosyltransferase (Fut8), the sole enzyme for catalyzing the core fucosylation of N-glycan, significantly reduced CD4+ T cell activation and ameliorated the… CONTINUE READING