Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML

  title={Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML},
  author={Rishi V. Puram and Monika S. Kowalczyk and Carl G. de Boer and Rebekka K Schneider and Peter G. G. Miller and Marie McConkey and Zuzana Tothova and H{\'e}ctor Tejero and Dirk Heckl and Marcus J{\"a}r{\aa}s and Michelle C. Chen and Hubo Li and Alfred Tamayo and Glenn S Cowley and Orit Rozenblatt-Rosen and F{\'a}tima Al-Shahrour and Aviv Regev and Benjamin L. Ebert},
Leukemia stem cells (LSCs) have the capacity to self-renew and propagate disease upon serial transplantation in animal models, and elimination of this cell population is required for curative therapies. Here, we describe a series of pooled, in vivo RNAi screens to identify essential transcription factors (TFs) in a murine model of acute myeloid leukemia (AML) with genetically and phenotypically defined LSCs. These screens reveal the heterodimeric, circadian rhythm TFs Clock and Bmal1 as genes… CONTINUE READING
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