Cordyceps Mushroom: A Potent Anticancer Nutraceutical

@article{Khan2010CordycepsMA,
  title={Cordyceps Mushroom: A Potent Anticancer Nutraceutical},
  author={Md Asaduzzaman Khan and M. Tania and Dianzheng Zhang and Han-chun Chen},
  journal={The Open Nutraceuticals Journal},
  year={2010},
  volume={3},
  pages={179-183}
}
The Cordyceps mushrooms have a long history as medicinal fungi. In Traditional Chinese Medicine, Cordyceps have been used to treat several conditions including cancers for thousand of years. Extracts from both mycelium and fruiting bodies of C. sinensis, C. militaris and other Cordyceps species showed significant anticancer activities by various mechanisms such as, modulating immune system and inducing cell apoptosis. Some polysaccharide components and cordycepin (3'-deoxyadenosine) have been… Expand
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References

SHOWING 1-10 OF 61 REFERENCES
Antifungal and Anticancer Activities of a Protein from the Mushroom Cordyceps militaris.
TLDR
Results indicate that C. militaris represents a source of a novel protein that might be applied in diverse biological and medicinal applications. Expand
Immunomodulatory and antitumour effects of an exopolysaccharide fraction from cultivated Cordyceps sinensis (Chinese caterpillar fungus) on tumour‐bearing mice
TLDR
The results suggest that EPSF has immunomodulatory function and antitumour activity in cultivated C. sinensis and its effects on B16 melanoma‐bearing mice were investigated. Expand
Effects of exopolysaccharide fraction (EPSF) from a cultivated Cordyceps sinensis fungus on c-Myc, c-Fos, and VEGF expression in B16 melanoma-bearing mice.
TLDR
The c-Myc, c-Fos, and VEGF levels in the lungs and livers of EPSF-treated mice were found to be significantly lower than those of untreated mice, suggesting that EPSF had inhibited tumor growth in the Lungs and Livers of mice, and that it might be a potential adjuvant in cancer therapy. Expand
Induction of apoptosis by Cordyceps militaris through activation of caspase-3 in leukemia HL-60 cells.
TLDR
Results indicate that the hot water extract of Cordyceps militaris fruiting bodies inhibited cancer cell proliferation by inducing cell apoptosis through the activation of caspase-3, and that the Cordyces militaris extract may therefore have therapeutic potential against human leukemia. Expand
Inhibitory effects of ethyl acetate extract of Cordyceps sinensis mycelium on various cancer cells in culture and B16 melanoma in C57BL/6 mice.
  • J. Wu, Q. Zhang, P. Leung
  • Biology, Medicine
  • Phytomedicine : international journal of phytotherapy and phytopharmacology
  • 2007
TLDR
The results suggest that the EtOAc extract of Cs fungal mycelium has strong anti-tumor activity and is a potential source of natural anti-Tumor products. Expand
Medicinal properties of substances occurring in higher basidiomycetes mushrooms: current perspectives (review).
TLDR
Clinical intervention studies have demonstrated the therapeutic importance of correcting the hypercholesterolemia and the initial step in lowering cholesterol is a special diet low in fat and saturated fatty acids and rich in crude fibers. Expand
Antitumor activity of an extract of Cordyceps sinensis (Berk.) Sacc. against murine tumor cell lines.
TLDR
The antitumor effect of ECS seen in the allogeneic mice was significantly reduced when the mice received whole body X-irradiation (5 Gy) before EAC implantation, and results suggest that the antitumors effect ofECS may be mediated through its immunomodulating action. Expand
Growth inhibition of U937 leukemia cells by aqueous extract of Cordyceps militaris through induction of apoptosis.
TLDR
The results indicated that the anti-proliferative effects of A ECM were associated with the induction of apoptotic cell death through regulation of several major growth regulatory gene products such as Bcl-2 family expression and caspase protease activity, and AECM may have therapeutic potential in human leukemia treatment. Expand
Antioxidative and antimutagenic activities of 70% ethanolic extracts from four fungal mycelia-fermented specialty rices.
TLDR
There is a possibility that such fermented rice may contribute to the prevention of lifestyle-related diseases such as cancer through a daily intake of rice-based diets. Expand
[Effects of Cordyceps sinensis (CS) on in vitro natural killer cells].
  • C. Liu, S. Lu, M. Ji
  • Medicine
  • Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine
  • 1992
TLDR
The results suggested that CS could be exploited and utilized as an approach of biological responsive modifier therapy (BRMT) in the treatment of leukemia. Expand
...
1
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