Cordycepin inhibits lipopolysaccharide-induced inflammation by the suppression of NF-kappaB through Akt and p38 inhibition in RAW 264.7 macrophage cells.

@article{Kim2006CordycepinIL,
  title={Cordycepin inhibits lipopolysaccharide-induced inflammation by the suppression of NF-kappaB through Akt and p38 inhibition in RAW 264.7 macrophage cells.},
  author={Ho Gyoung Kim and Bhushan Shrestha and So Yeon Lim and Deok Hyo Yoon and Woo Chul Chang and Dong-jik Shin and Sang Kuk Han and Sang Min Park and Jung Hee Park and Hae Il Park and Jae-Mo Sung and Yangsoo Jang and Namsik Chung and K. T. Hwang and Tae Woong Kim},
  journal={European journal of pharmacology},
  year={2006},
  volume={545 2-3},
  pages={192-9}
}
Cordyceps militaris, a caterpillar-grown traditional medicinal mushroom, produces an important bioactive compound, cordycepin (3'-deoxyadenosine). Cordycepin is reported to possess many pharmacological activities including immunological stimulating, anti-cancer, anti-virus and anti-infection activities. The molecular mechanisms of cordycepin on pharmacological and biochemical actions of macrophages in inflammation have not been clearly elucidated yet. In the present study, we tested the role of… CONTINUE READING

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