• Corpus ID: 38002620

Cordycepin induces apoptosis in human neuroblastoma SK-N-BE(2)-C and melanoma SK-MEL-2 cells.

  title={Cordycepin induces apoptosis in human neuroblastoma SK-N-BE(2)-C and melanoma SK-MEL-2 cells.},
  author={Ji-Sue Baik and Haw-Young Kwon and Kyoung-sook Kim and Yong-Ki Jeong and Young-Su Cho and Young-Choon Lee},
  journal={Indian journal of biochemistry \& biophysics},
  volume={49 2},
In this study, the effect of cordycepin (3'-deoxyadenosine), a major component of Cordyceps militaris, an ingredient of traditional Chinese medicine was investigated for the first time on apoptotsis in human neuroblastoma SK-N-BE(2)-C and melanoma SK-MEL-2 cells. Cordycepin significantly inhibited the proliferation of human neuroblastoma SK-N-BE(2)-C and human melanoma SK-MEL-2 cells with IC50 values of 120 microM and 80 microM, respectively. Cordycepin treatment at 120 microM and 80 microM… 
Anti-cancer effect and apoptosis induction of cordycepin through DR3 pathway in the human colonic cancer cell HT-29.
Cordycepin induced apoptosis through the DR3 pathway in human colon cancer HT-29 in a dose-dependent manner as detected by Hoechst and Annexin V-FITC staining and these findings suggest that cordyce pin should be evaluated further as a therapeutic agent in human Colon cancer.
Involvement of autophagy in cordycepin-induced apoptosis in human prostate carcinoma LNCaP cells.
The results show that cordycepin resulted in significant reduction in LNCaP cell survival by inducing apoptotic cell death and suggest that autophagy is a potential strategy for treating prostate cancer that is resistant to pro-apoptotic therapeutics.
Apoptosis and inhibition of proliferation of cancer cells induced by cordycepin.
These studies demonstrate that cordycepin may be used as a natural medicine, as it can not only control tumor cell proliferation, but also induce cancer cell apoptosis.
Triptolide-Mediated Apoptosis by Suppression of Focal Adhesion Kinase through Extrinsic and Intrinsic Pathways in Human Melanoma Cells
It is demonstrated that TPL induces apoptosis by both extrinsic and intrinsic apoptosis pathways in human melanoma cells and identified that RIP shuttles between Fas and FAK to mediate apoptosis.
Involvement of p38 MAPK in the Anticancer Activity of Cultivated Cordyceps militaris.
It is found that a p38 MAPK inhibitor but not an AKT inhibitor could rescue cells from CM-mediated cell death, as well as inhibit the cleavage of PARP, formation of apoptotic bodies and up-regulation of the γH2AX signal.
Cordycepin Enhances Radiosensitivity in Oral Squamous Carcinoma Cells by Inducing Autophagy and Apoptosis Through Cell Cycle Arrest
The combination of cordycepin and IR treatment could be a potential therapeutic strategy for OSCC by inducing apoptosis, cell cycle arrest, and autophagic cell death in human oral cancer cells.
Synergistic property of cordycepin in cultivated Cordyceps militaris-mediated apoptosis in human leukemia cells.
  • S. Chou, W. Lai, +9 authors T. Shen
  • Biology, Medicine
    Phytomedicine : international journal of phytotherapy and phytopharmacology
  • 2014
It is suggested that cordycepin possesses a synergistic cytotoxic effect with Cordyceps militaris-mediated apoptosis in human leukemia cells and therefore explaining a better anti-proliferating activity of CM(FB) over CM(MY).
Cordyceps militaris (L.) Link Fruiting Body Reduces the Growth of a Non-Small Cell Lung Cancer Cell Line by Increasing Cellular Levels of p53 and p21
This work suggests that the methanolic extract of C. militaris affected NCI-H460 cellular viability through a mechanism involving DNA damage and p53 activation, which supports the potential of this extract as a source of bioactive compounds, which may be used in anticancer strategies.
Cordycepin in Anticancer Research: Molecular Mechanism of Therapeutic Effects.
Ongoing research studies have reported highly potential anticancer activities of cordycepin with numerous molecular mechanisms, and this molecule might be used for development of future cancer drug.
The Anticancer Properties of Cordycepin and Their Underlying Mechanisms
This review provides the molecular mechanisms by which cordycepin functions as a singular or combinational anticancer therapeutic agent.


Cordycepin is an immunoregulatory active ingredient of Cordyceps sinensis.
Corycepin could be an important immunoregulatory active ingredient in Cordyceps sinensis and may contain substances which possess synergism with cordycepin, as CS showed a higher efficiency in the production of IL-10 and IL-2 than cordycespin.