Cordlan polysaccharide isolated from mushroom Cordyceps militaris induces dendritic cell maturation through toll-like receptor 4 signalings.

@article{Kim2010CordlanPI,
  title={Cordlan polysaccharide isolated from mushroom Cordyceps militaris induces dendritic cell maturation through toll-like receptor 4 signalings.},
  author={Hyung Sook Kim and Jee Youn Kim and Jong Soon Kang and Hwan‐Mook Kim and Yong Ok Kim and I. P. Hong and Mi Kyeong Lee and Jin Tae Hong and Youngsoo Kim and Sang Bae Han},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={2010},
  volume={48 7},
  pages={
          1926-33
        }
}
  • Hyung Sook Kim, J. Kim, S. Han
  • Published 1 July 2010
  • Biology
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
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Water extract of Cordyceps militaris enhances maturation of murine bone marrow-derived dendritic cells in vitro.
TLDR
Water extract of Cordyceps militaris induces the phenotypic and functional maturation of dendritic cells (DC) and is shown to promote the cytotoxicity of specific-cytotoxic T lymphocytes induced by DC which were pulsed with P815 tumor-lysate during the stage of antigen presentation.
Proteoglycan isolated from Phellinus linteus induces toll-like receptors 2- and 4-mediated maturation of murine dendritic cells via activation of ERK, p38, and NF-kappaB.
TLDR
It is demonstrated that PL stimulation could induce the phenotypic and functional maturation of DC via TLR2 and/or TLR4 mediated-NF-kappaB, ERK and p38 MAPK signal pathways and Toll-like receptors may be the receptor(s) of PL.
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