Cord blood rescues stroke-induced changes in splenocyte phenotype and function

@article{Vendrame2006CordBR,
  title={Cord blood rescues stroke-induced changes in splenocyte phenotype and function},
  author={Martina Vendrame and Carmelina Gemma and Keith R. Pennypacker and Paula C. Bickford and Cyndy Davis Sanberg and Paul Sanberg and Alison E Willing},
  journal={Experimental Neurology},
  year={2006},
  volume={199},
  pages={191-200}
}
Amelioration of Ischemic Brain Injury in Rats with Human Umbilical Cord Blood Stem Cells: Mechanisms of Action
TLDR
Data suggest that nh-UCBSCs may act by inhibiting immune cell migration into the brain from the periphery and possibly by inhibition of immune cell activation within the brain.
Human umbilical cord blood cells directly suppress ischemic oligodendrocyte cell death
TLDR
It is likely that HUCBC administration directly protects oligodendrocytes and white matter and this effect is likely to contribute to the increased behavioral recovery observed with H UCBC therapy.
Assessment of Neuroprotective Effects of Human Umbilical Cord Blood Mononuclear Cell Subpopulations In Vitro and in Vivo
TLDR
This study suggests that MNCs provide the most prominent neuroprotective effect, with CD34+ cells seeming to be particularly involved in the protective action of M NCs.
Human Umbilical Cord Blood Cells Alter Blood and Spleen Cell Populations After Stroke
TLDR
The results suggest that the effects of H UCB MNC in the spleen are not due to a single HUCB population, but the interaction of all the subpopulations together.
A Transient Decrease in Spleen Size Following Stroke Corresponds to Splenocyte Release into Systemic Circulation
TLDR
The spleen was found to significantly decrease in size from 24 to 48 h following middle cerebral artery occlusion (MCAO) in rats compared to sham operated controls, and CFSE labeled cells migrated to the brain following MCAO but appear to remain within the vasculature.
Leukemia inhibitory factor modulates the peripheral immune response in a rat model of emergent large vessel occlusion
TLDR
These data demonstrate that LIF promotes anti-inflammatory signaling through alterations of the IL-12/interferon gamma/Interferon inducible protein 10 pathway.
Splenectomy protects experimental rats from cerebral damage after stroke due to anti‐inflammatory effects
TLDR
The mechanism(s) by which splenectomy protects brain from damage induced by stroke may correlate with the decreased numbers of inflammatory cells and changes in inflammatory cytokines.
Multipotent Adult Progenitor Cells Enhance Recovery After Stroke by Modulating the Immune Response from the Spleen
TLDR
Investigation of the impact of human multipotent adult progenitor cells (MAPC) modulating splenic activation and peripheral immune responses after ischemic stroke found it restores expression of multiple genes and pathways involved in immune and inflammatory responses after stroke.
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References

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Anti-inflammatory effects of human cord blood cells in a rat model of stroke.
TLDR
It is proposed that cord blood treatment in stroke reduces inflammation and provides neuroprotection and is demonstrated that the cord blood cells increase neuronal survival through non-immune mechanisms.
Mobilized Peripheral Blood Cells Administered Intravenously Produce Functional Recovery in Stroke
TLDR
In both transplanted groups of rats, a significant reduction of the stroke-induced hyperactivity was observed compared with nontransplanted, stroked animals and the possibility that PBPCs could provide a novel transplantation therapy to treat stroke is raised.
Administration of CD34+ cells after stroke enhances neurogenesis via angiogenesis in a mouse model.
TLDR
It is demonstrated that systemic administration of human cord blood-derived CD34(+) cells to immunocompromised mice subjected to stroke 48 hours earlier induces neovascularization in the ischemic zone and provides a favorable environment for neuronal regeneration.
Timing of Cord Blood Treatment after Experimental Stroke Determines Therapeutic Efficacy
TLDR
Intravenous delivery of human umbilical cord blood cells 48 h after a middle cerebral artery occlusion in a rat resulted in both behavioral and physiological recovery and should offer encouragement to clinicians that a therapy with a broader window of efficacy may soon be available to treat stroke.
Infusion of Human Umbilical Cord Blood Cells in a Rat Model of Stroke Dose-Dependently Rescues Behavioral Deficits and Reduces Infarct Volume
TLDR
Previous observations of H UCBC infusion in the MCAO rat stroke model are extended by demonstrating a dose relationship between HUCBC, behavioral improvement, and neuronal sparing.
Mucosal tolerance to E-selectin provides cell-mediated protection against ischemic brain injury
TLDR
Results indicate that, in addition to preventing stroke, mucosal tolerance to E-selectin is cytoprotective, and immunomodulation targeted to activated blood vessel segments can both reduce stroke occurrence and attenuate brain damage if a stroke supervenes.
Intravenous versus intrastriatal cord blood administration in a rodent model of stroke
TLDR
It is suggested that hUCB transplantation may be an effective treatment for brain injuries, such as stroke, or neurodegenerative disorders, and intravenous delivery may be more effective than striatal delivery in producing long‐term functional benefits to the stroked animal.
Central Nervous System Entry of Peripherally Injected Umbilical Cord Blood Cells Is Not Required for Neuroprotection in Stroke
TLDR
The data show that central nervous system availability of grafted cells is not a prerequisite for acute neuroprotection provided that therapeutic molecules secreted by these cells could cross the BBB.
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