Cord blood rescues stroke-induced changes in splenocyte phenotype and function

  title={Cord blood rescues stroke-induced changes in splenocyte phenotype and function},
  author={M. Vendrame and C. Gemma and K. Pennypacker and P. Bickford and A. Willing},
  journal={Experimental Neurology},
  • M. Vendrame, C. Gemma, +2 authors A. Willing
  • Published 2006
  • Medicine
  • Experimental Neurology
  • The neuroprotective mechanism of human umbilical cord blood cells (HUCBC) in the rat middle cerebral artery occlusion (MCAO) stroke model remains uncertain. Given the inflammatory sequelae that occur following stroke, we investigated whether HUCBC protection could be derived from the modulation of this immuno-inflammatory event, suggested by the attraction of the HUCBC to the spleen. We found that, following MCAO, rat spleen size was reduced concomitantly with their CD8+ T-cell counts… CONTINUE READING
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