Cord blood mononuclear cells prevent neuronal apoptosis in response to perinatal asphyxia in the newborn lamb.

@article{Aridas2016CordBM,
  title={Cord blood mononuclear cells prevent neuronal apoptosis in response to perinatal asphyxia in the newborn lamb.},
  author={James D S Aridas and Courtney A McDonald and Madison C. B. Paton and Tamara Yawno and Amy Elizabeth Sutherland and Ilias Nitsos and Yen H Pham and Michael R. Ditchfield and Michael C. Fahey and Flora S Y Wong and Atul Malhotra and Margie Castillo-Mel{\'e}ndez and Kishore Kumar Bhakoo and Euan M Wallace and Graham Jenkin and Suzanne L Miller},
  journal={The Journal of physiology},
  year={2016},
  volume={594 5},
  pages={1421-35}
}
Perinatal asphyxia is a significant cause of death or long-term neurodevelopmental impairment. Hypothermia, currently the only effective treatment, leads to modest improvements, but new therapeutic strategies are required. Umbilical cord blood (UCB) mononuclear cells have potent anti-inflammatory properties and may reduce neuropathology. This study examined whether autologous UCB mononuclear cells were neuroprotective when administered to newborn lambs at 12 h after birth asphyxia. At caesarean… CONTINUE READING
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