Cord blood mesenchymal stem cells propel human dendritic cells to an intermediate maturation state and boost interleukin-12 production by mature dendritic cells.

@article{Berk2009CordBM,
  title={Cord blood mesenchymal stem cells propel human dendritic cells to an intermediate maturation state and boost interleukin-12 production by mature dendritic cells.},
  author={Lieke C J van den Berk and Helene Roelofs and Tonnie Huijs and Kim G C Siebers-Vermeulen and Reinier A. P. Raymakers and Gesine Koegler and Carl G. Figdor and Ruurd Torensma},
  journal={Immunology},
  year={2009},
  volume={128 4},
  pages={564-72}
}
Pathogen-derived entities force the tissue-resident dendritic cells (DCs) towards a mature state, followed by migration to the draining lymph node to present antigens to T cells. Bone marrow mesenchymal stem cells (MSCs) modulate the differentiation, maturation and function of DCs. In umbilical cord blood an immature MSC population was identified. Remarkably, these immature stem cells modulated DCs in a different way. Marker expression was unchanged during the differentiation of monocytes… CONTINUE READING

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