Cord blood CD34+ cells expanded on Wharton's jelly multipotent mesenchymal stromal cells improve the hematopoietic engraftment in NOD/SCID mice.

@article{Milazzo2014CordBC,
  title={Cord blood CD34+ cells expanded on Wharton's jelly multipotent mesenchymal stromal cells improve the hematopoietic engraftment in NOD/SCID mice.},
  author={Luisa Milazzo and Francesca Vulcano and Alessandra Barca and Giampiero Macioce and Emanuela Paldino and Stefania Rossi and Carmela Ciccarelli and Hamisa Jane Hassan and Adele Giampaolo},
  journal={European journal of haematology},
  year={2014},
  volume={93 5},
  pages={384-91}
}
OBJECTIVE This study aims to investigate the capability of Wharton's jelly multipotent mesenchymal stromal cells (WJ-MSC) to support the in vitro expansion of hematopoietic stem/progenitor cells (HSPC) derived from cord blood (CB) in the absence of exogenous cytokines, and the effect on engraftment of the expanded cells in a mouse model. METHODS CB-CD34+ cells were seeded on WJ-MSC layer and cultured in HP01 serum-free medium. Day-7 and day-13 expanded cells were transplanted in NOD/SCID mice… CONTINUE READING
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