Cord Blood Derived CD4+CD25high T Cells Become Functional Regulatory T Cells upon Antigen Encounter

@inproceedings{Mayer2012CordBD,
  title={Cord Blood Derived CD4+CD25high T Cells Become Functional Regulatory T Cells upon Antigen Encounter},
  author={Elisabeth Mayer and Christina Bannert and Saskia Gruber and Sven Klunker and Andreas Spittler and Cezmi A. Akdis and Zsolt Sz{\'e}pfalusi and Thomas Eiwegger},
  booktitle={PloS one},
  year={2012}
}
BACKGROUND Upon antigen exposure, cord blood derived T cells respond to ubiquitous environmental antigens by high proliferation. To date it remains unclear whether these "excessive" responses relate to different regulatory properties of the putative T regulatory cell (Treg) compartment or even expansion of the Treg compartment itself. METHODS Cord blood (>37 week of gestation) and peripheral blood (healthy controls) were obtained and different Treg cell subsets were isolated. The suppressive… CONTINUE READING

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