Coq3 and Coq4 define a polypeptide complex in yeast mitochondria for the biosynthesis of coenzyme Q.

@article{Marbois2005Coq3AC,
  title={Coq3 and Coq4 define a polypeptide complex in yeast mitochondria for the biosynthesis of coenzyme Q.},
  author={B. Noelle Marbois and Peter M. W. Gin and Kym F. Faull and Wayne W S Poon and Peter T. K. Lee and Jeff R. Strahan and Jennifer N Shepherd and Catherine F. Clarke},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 21},
  pages={
          20231-8
        }
}
Coenzyme Q (Q) is a redox active lipid essential for aerobic respiration in eukaryotes. In Saccharomyces cerevisiae at least eight mitochondrial polypeptides, designated Coq1-Coq8, are required for Q biosynthesis. Here we present physical evidence for a coenzyme Q-biosynthetic polypeptide complex in isolated mitochondria. Separation of digitonin-solubilized mitochondrial extracts in one- and two-dimensional Blue Native PAGE analyses shows that Coq3 and Coq4 polypeptides co-migrate as high… CONTINUE READING
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